Pharma BD Deal Intelligence
Early-stage breast-cancer in-license, milestone-weighted
Full analysis, sources & comparables →Astex grants Genentech an exclusive worldwide license to its FBDD breast-cancer program; >$490M upfront+milestones plus tiered royalties.
Genentech signs breast-cancer discovery deal with Otsuka's Astex worth up to ~$515M in upfront and milestones.
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Astex Pharmaceuticals (an Otsuka company) announced on July 6, 2026 an exclusive, worldwide research collaboration and license agreement with Genentech (a member of the Roche Group) to develop small-molecule inhibitors of a key cell-cycle-dependent regulator as potential breast-cancer therapies. Astex receives USD 25 million upfront and is eligible for preclinical, clinical, regulatory and sales milestones totaling more than USD 490 million, plus tiered royalties. Astex grants Genentech an exclusive license to compounds from its existing breast-cancer discovery program (originating from work with Newcastle University and Cancer Research Horizons); Genentech takes sole responsibility for preclinical/clinical development and global commercialization.
| Deal | Year | Value | Outcome |
|---|---|---|---|
| Genentech, Inc. (Roche Group) / Astex Pharmaceuticals (this deal) | 2026 | $490M | 58 |
| Genentech, Inc. (Roche Group) / Tanox Inc. | 2006 | $919M | 80 |
| Genentech, Inc. (Roche Group) / Affimed N.V. | 2018 | $5.1B | — |
| Genentech, Inc. (Roche Group) / Hanmi Pharmaceutical Co. Ltd. | 2016 | $910M | — |
| Genentech, Inc. (Roche Group) / Regor Pharmaceuticals Inc. | 2024 | $850M | — |
| Genentech, Inc. (Roche Group) / OMass Therapeutics Ltd. | 2025 | $420M | — |
| Genentech, Inc. (Roche Group) / MaxCyte, Inc. | 2026 | — | — |
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More: 2026 deals · Genentech, Inc. (Roche Group) deals · Oncology deals