BeOne Medicines entered a global exclusive option, license and collaboration agreement with China-based Huahui Health for trispecific antibody HH160; $20M upfront, $100M option-exercise payment, and up to $1.9B in development/regulatory/commercial milestones, totaling ~$2.02B excluding royalties.
MechanismTrispecific antibody simultaneously targeting PD-1, CTLA-4 and VEGF-A to combine checkpoint inhibition with anti-angiogenic activity in a single molecule