Pharma BD Deal Intelligence

Royalty Pharma / Biohaven Pharmaceutical Holding Co. Ltd. (rimegepant funding)

2019 · Co-Development · $200M · Complete

Non-dilutive financing that paid off: Royalty Pharma put $125 million into Biohaven's rimegepant NDA push at closing, with up to $75 million more on FDA acceptance, ultimately funding a franchise that Pfizer paid $150 million upfront plus $350 million equity to buy the ex-US rights to.

Outcome grade pending — assessed 5 years post-close.

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The coverage arc

Jun 19, 2018 Royalty Pharma Bullish

Royalty Pharma acquired royalty rights on global sales of rimegepant (BHV-3000) and BHV-3500 for $100M, with tiered royalties starting at 2.10% on annual net…

Aug 07, 2020 PR Newswire / Biohaven Bullish

Biohaven and Royalty Pharma expanded the partnership with a $450M package — up to $250M for zavegepant funding (3% royalty plus 0.4% on Nurtec ODT) and…

Nov 09, 2021 BioPharma Dive Neutral

BioPharma Dive validated the Royalty Pharma thesis ex-post: Pfizer paid $150M upfront plus $350M equity at a 25% premium for ex-US Nurtec rights after the drug…

Source summaries from our enrichment pipeline; follow links for originals.

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Royalty Pharma agreed to purchase up to $200M in Series A Preferred Shares of Biohaven to fund Biohaven's $105M acquisition of an FDA Priority Review Voucher and general corporate uses for the rimegepant NDA. Royalty Pharma provided $125M at closing with up to an additional $75M available upon FDA acceptance of the rimegepant NDA.

Key facts

Disease & market context

Migraine

$7.0B Global migraine drugs market 2021 (USD millions)

Disease Overview

Migraine is a recurrent, often disabling neurological disorder marked by moderate-to-severe pulsating headache, typically with nausea, photophobia, and phonophobia. It disproportionately affects women of reproductive age and is the third most common reason for ED visits among women 15-64. Despite high prevalence, prior to the CGRP era many patients failed or could not tolerate triptans, leaving large unmet need across both acute and preventive treatment.

Competitive Landscape

By 2019 the migraine market was bifurcating along CGRP mechanism lines. Three injectable anti-CGRP monoclonal antibodies dominated prevention: Amgen/Novartis Aimovig (erenumab, 2018), Teva Ajovy (fremanezumab, 2018), and Lilly Emgality (galcanezumab, 2018), with Lundbeck/Alder Vyepti (eptinezumab) IV following in 2020. The acute oral CGRP receptor antagonist (gepant) class opened with Allergan/AbbVie Ubrelvy (ubrogepant, Dec 2019) and Biohaven Nurtec ODT (rimegepant, Feb 2020), followed by AbbVie Qulipta (atogepant, 2021) for prevention. Rimegepant differentiated on a single oral disintegrating tablet that ultimately won both acute and preventive labels — the only gepant to do so at launch — and posted ~57% share of the US oral CGRP market by Q3 2021 with $136M quarterly sales. The Royalty Pharma financing was strategically pivotal: it provided non-dilutive capital so Biohaven could fund a full DTC commercial launch against AbbVie's marketing scale, ultimately enabling the $11.6B Pfizer acquisition in 2022. Royalty Pharma's stacked exposure (royalties + preferred equity + zavegepant) became one of the firm's highest-profile CNS bets.

Related deals — scored

DealYearValueOutcome
Royalty Pharma / Biohaven Pharmaceutical Holding Co. Ltd. (rimegepant funding) (this deal)2019$200M
Royalty Pharma / Zealand Pharma A/S2026$100M
Royalty Pharma / Neurimmune AG (NI006 license)2026$425M
Royalty Pharma / Ionis2023$1.1B
Royalty Pharma / BeOne Medicines Ltd.2025$950M
Royalty Pharma / ImmuNext, Inc.2024$525M
Royalty Pharma / Geron2024$125M

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