Pharma BD Deal Intelligence

Roche Holding AG / Prothena Corporation plc

2013 · Licensing/Option · $630M · Complete

Outcome grade pending — assessed 5 years post-close.

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The coverage arc

Dec 11, 2013 BioSpace Bullish

Roche inks deal worth up to $600 million for Prothena's Parkinson's drug PRX002; Prothena shares rose about 7.7% in after-market trading following the…

Mar 01, 2014 Nature Biotechnology Neutral

At deal signing, Nature Biotechnology framed Roche's $30M upfront / up to $600M biobucks bet on Prothena as the highest-profile alpha-synuclein wager in…

Jun 16, 2025 BioPharma Dive Neutral

Roche committed to Phase 3 prasinezumab despite Pasadena and Padova both missing primary endpoints; Prothena has collected $135M of up to $630M deal value…

Source summaries from our enrichment pipeline; follow links for originals.

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Roche/Prothena License, Development & Commercialisation agreement for anti-alpha-synuclein mAbs (prasinezumab); $30M upfront + up to $600M milestones + US profit share + ex-US royalties.

Did it work? Outcome assessment

Strategic verdict
Too Early
Financial impact
Neutral
Pipeline outcome
Assets Advanced

Key facts

Related deals — scored

DealYearValueOutcome
Roche Holding AG / Prothena Corporation plc (this deal)2013$630M
Roche Holding AG / Chugai Pharmaceutical Co. Ltd.2002$1.4B100
Roche Holding AG / Ventana Medical Systems Inc.2008$3.4B88
Roche Holding AG / Corange Ltd. (Boehringer Mannheim Group)1997$11.0B88
Roche Holding AG / Ventana Medical Systems Inc.2007$3.4B88
Roche Holding AG / Foundation Medicine, Inc.2015$1.1B87
Roche Holding AG / Foundation Medicine, Inc.2018$5.3B85

Compare all 7 side-by-side →

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