Pharma BD Deal Intelligence

GlaxoSmithKline plc / Merck KGaA

2019 · Co-Development · $4.2B · Complete

CALLED IT — OFF BY 11
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Top 25 biggest flops we track

Ranks computed across 828 graded deals (Critic + Outcome Score both present).

The coverage arc

Sep 30, 2021 Bearish

GSK $4.2B bet on Merck KGaA bintrafusp alfa goes up in smoke as pharmas cut ties after series of clinical trial flops in lung cancer indications.

Apr 24, 2026 BioPharm International Bullish

GSK and Merck KGaA partnered in a $4.2 billion cancer immunotherapy deal centered on M7824, with Merck receiving EUR 300 million upfront and potential…

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GSK and Merck KGaA entered a global alliance to co-develop bintrafusp alfa (M7824), a bifunctional TGF-beta trap/anti-PD-L1 fusion protein. Deal terminated in 2021 after clinical failures.

Key facts

Related deals — scored

DealYearValueOutcome
GlaxoSmithKline plc / Merck KGaA (this deal)2019$4.2B29
GlaxoSmithKline plc / Theravance, Inc.2012$213M82
GlaxoSmithKline plc / Tesaro Inc.2018$5.1B79
GlaxoSmithKline plc / Pfizer Inc. (Consumer Healthcare Division)2018$12.7B76
GlaxoSmithKline plc / Novartis Consumer Healthcare JV2018$13.0B74
GlaxoSmithKline plc / ID Biomedical Corporation2005$1.4B64
GlaxoSmithKline plc / Vir Biotechnology Inc.2020$595M51

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