Pharma BD Deal Intelligence

Genmab A/S / Merus N.V.

2025 · Acquisition/Merger · $8.0B · Complete

Outcome grade pending — assessed 5 years post-close.

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The coverage arc

Sep 29, 2025 BioCentury Bullish

Genmab's $8B Merus takeout is latest push toward full ownership of programs. The company stated the deal would provide late-stage cancer asset petosemtamab, an…

Sep 29, 2025 Fierce Biotech Bullish

Genmab is paying $8 billion to acquire Merus and its late-stage bispecific antibody petosemtamab, the companies said Monday. The deal, Genmab's largest ever,…

Sep 29, 2025 STAT News Bullish

Genmab to buy Merus in $8B deal. The acquisition centers on Merus' experimental cancer drug petosemtamab. In May 2025, the company reported that when combined…

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Genmab acquired Merus for $97.00/share cash, total transaction value ~$8.0B. The tender offer (via subsidiary Genmab Holding II B.V.) completed and the acquisition closed on December 12, 2025, making Merus a wholly owned subsidiary of Genmab. The deal adds petosemtamab, an EGFRxLGR5 bispecific with two Breakthrough Therapy Designations for 1L and 2L+ head and neck cancer (SCCHN); Phase 2 data at ASCO 2025 showed ORR and PFS substantially above standard of care. Phase 3 trials (LiGeR-HN1, NCT06525220, 1L petosemtamab + pembrolizumab; and a 2L+ trial) are ongoing with topline readouts anticipated in 2026. Genmab targets an initial petosemtamab launch in 2027 and expects the asset to be EBITDA-accretive with >$1B annual sales potential by 2029. Funded via cash on hand plus ~$5.5B of non-convertible debt financing.

Key facts

Related deals — scored

DealYearValueOutcome
Genmab A/S / Merus N.V. (this deal)2025$8.0B
Genmab A/S / ProfoundBio Inc.2024$1.8B64
Genmab A/S / Bolt Biotherapeutics, Inc.2021$880M
AstraZeneca PLC / Daiichi Sankyo Company, Limited2019$6.9B100
Novartis AG / Endocyte, Inc.2018$2.1B96
Astellas Pharma Inc. / Seagen Inc.2009$4.5B95
Bristol-Myers Squibb Company / Medarex Inc.2009$2.4B92

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