Pharma BD Deal Intelligence

Eli Lilly and Company / Rigel Pharmaceuticals, Inc.

2021 · Licensing/Option · $960M · Terminated

Outcome grade pending — assessed 5 years post-close.

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The coverage arc

Feb 18, 2021 BusinessWire Bullish

Eli Lilly and Rigel Pharmaceuticals announced a strategic collaboration to co-develop and commercialize R552, an investigational RIPK1 inhibitor, for…

Feb 19, 2021 BioWorld Neutral

Eli Lilly has agreed to pay Rigel Pharmaceuticals $125 million upfront plus up to $835 million in milestones for global rights to R552, Rigel's RIPK1 inhibitor…

Mar 12, 2025 Rigel Press Release (rights return) Bearish

Rigel Pharmaceuticals announced that Eli Lilly has elected to return all rights to R552 (ocadusertib) and the broader RIPK1 inhibitor program to Rigel under…

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Eli Lilly and Rigel entered a strategic collaboration to develop and commercialize RIPK1 inhibitors for inflammatory and autoimmune indications, plus CNS-penetrant RIPK1 candidates. Lilly paid $125M upfront and Rigel was eligible for up to $835M in development, regulatory and commercial milestones plus tiered royalties.

Key facts

Related deals — scored

DealYearValueOutcome
Eli Lilly and Company / Rigel Pharmaceuticals, Inc. (this deal)2021$960M
Eli Lilly and Company / Boehringer Ingelheim GmbH2011$444M89
Eli Lilly and Company / Loxo Oncology, Inc.2019$8.0B88
Eli Lilly and Company / Applied Molecular Evolution Inc.2003$400M88
Eli Lilly and Company / ICOS Corporation2006$2.3B87
Eli Lilly and Company / Novartis Animal Health2014$5.4B70
Eli Lilly and Company / Incyte Corporation2009$755M69

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