Pharma BD Deal Intelligence

AstraZeneca PLC / Pinetree Therapeutics, Inc.

2026 · Licensing/Option · $500M · Complete

Outcome grade pending — assessed 5 years post-close.

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The coverage arc

Jul 15, 2024 PR Newswire (Original 2024 Pinetree) Neutral

Pinetree announced the exclusive option and global license agreement with AstraZeneca for its preclinical EGFR degrader candidate, with $45 million in upfront…

Apr 29, 2026 Morningstar (PR Newswire) Bullish

Pinetree Therapeutics announced AstraZeneca's exercise of the exclusive option to license the global rights to PTX-299, a first-in-class bispecific antibody…

Apr 30, 2026 AllSci Bullish

AstraZeneca converted a preclinical option into an exclusive global license agreement with Pinetree Therapeutics, triggering a $25 million payment. Pinetree…

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AstraZeneca exercised its exclusive option to globally license Pinetree's preclinical EGFR degrader PTX-299, triggering a $25M option-closing payment plus future development, regulatory and commercial milestones and tiered royalties; total potential value exceeds $500M.

Key facts

Related deals — scored

DealYearValueOutcome
AstraZeneca PLC / Pinetree Therapeutics, Inc. (this deal)2026$500M
AstraZeneca PLC / Daiichi Sankyo Company, Limited2019$6.9B100
AstraZeneca PLC / KuDOS Pharmaceuticals Limited2005$210M98
AstraZeneca PLC / Alexion Pharmaceuticals Inc.2020$39.0B86
AstraZeneca PLC / Acerta Pharma2015$4.0B86
AstraZeneca PLC / Amgen Inc.2020$2.3B84
AstraZeneca PLC / MedImmune Inc.2007$15.6B82

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