Home / Episodes / Mon, Sep 21, 2026

Novo’s Obesity Choices & Ivonescimab’s Global Test

Mon, Sep 21, 2026 15 min Hosts: Alex Mercer & Maya Patel
▶ Listen

Novo adds obesity programs as its Ascendis collaboration ends, while ivonescimab's China survival results sharpen the test facing its global lung-cancer program. Europe moves Corcept's Lifyorli toward authorization and backs broader perioperative use of Padcev with Keytruda, while Bayer's Kerendia, Vera's Trutakna, Xenon's azetukalner and Vertex's pediatric cystic-fibrosis applications show different regulatory and evidence paths. Gilead's lenacapavir agreements separate preparation for an investigational annual formulation from procurement of the approved twice-yearly option, with Merck's Winrevair label review and Novo's investor day ahead. Alex Mercer and Maya Patel host. Get the daily rundown in your inbox — subscribe at https://thepharmacloseout.com.

Close out your day

The whole read, every morning

The daily Closeout in under 15 minutes — trial readouts, FDA decisions, and the deal math behind them. Free.

Subscribe →