Pharma BD Deal Intelligence
Not actually an acquisition — a $260M CNS collaboration that Takeda quietly walked away from in 2024 despite positive late-breaking data
Full analysis, sources & comparables →FierceBiotech framed the pact as a strategic fit for Takeda's neuro-focused R&D restructuring, giving the buyer optionality across four genetically defined CNS…
Endpoints reported Takeda and Wave revised the original 2018 deal to drop the joint discovery component, signaling reduced commitment after the Phase 1 HD…
Takeda walked away from the Wave Huntington's collaboration after deploying roughly $260M, ending the 2018 alliance with no approved product to show for it.
Source summaries from our enrichment pipeline; follow links for originals.
All 6 sources with sentiment breakdown →
Takeda and Wave Life Sciences formed a global strategic collaboration in February 2018 to develop nucleic acid therapies for CNS disorders. Takeda paid $110M upfront, $60M in equity at $54.70/share, and committed at least $60M in research funding over four years. Total deal could reach ~$2B+ across four lead programs (HD, ALS, FTD, SCA3) plus options on multiple preclinical programs targeting Alzheimer's and Parkinson's.
Not actually an acquisition — a $260M CNS collaboration that Takeda quietly walked away from in 2024 despite positive late-breaking data
Assessment window: 10yr post-close.
| Deal | Year | Value | Outcome |
|---|---|---|---|
| Takeda Pharmaceutical Company Ltd. / Wave Life Sciences Ltd. (this deal) | 2018 | $2.0B | 22 |
| Takeda Pharmaceutical Company Ltd. / Nimbus Lakshmi | 2022 | $6.0B | 82 |
| Takeda Pharmaceutical Company Ltd. / Millennium Pharmaceuticals | 2003 | $8.8B | 82 |
| Takeda Pharmaceutical Company Ltd. / Ariad Pharmaceuticals | 2003 | $5.2B | 77 |
| Takeda Pharmaceutical Company Ltd. / Nycomed | 2011 | $13.7B | 72 |
| Takeda Pharmaceutical Company Ltd. / Millennium Pharmaceuticals | 2008 | $8.8B | 68 |
| Takeda Pharmaceutical Company Ltd. / Denali Therapeutics Inc. | 2018 | $1.2B | 64 |
← Browse all deals · How we score deals
More: 2018 deals · Takeda Pharmaceutical Company Ltd. deals · Neurology deals