Pharma BD Deal Intelligence
A $1.5B all-cash acquisition that gave Novartis a clinical-stage gene therapy for retinal disease, but the deal has since scored as a bust—Gyroscope's pipeline failed to deliver the outcomes Novartis was betting on.
Novartis acquired Gyroscope Therapeutics for $1.5B for gene therapy for retinal diseases.
Novartis to acquire Gyroscope Therapeutics for up to $1.5 billion for gene therapy targeting geographic atrophy.
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Novartis acquired Gyroscope Therapeutics for $1.5B for gene therapy for retinal diseases.
200K US cases/yr · $1.2B Global GA Market (2024)
GA is advanced dry AMD causing irreversible vision loss in ~5M globally. Complement inhibitors first approved treatments. Gene therapy aims for sustained delivery.
Apellis (Syfovre), Astellas (Izervay) approved. Novartis/Gyroscope gene therapy (GT005, CFI delivery) aims for one-time vs monthly injections.
Novartis completed $1.5B acquisition of Gyroscope Therapeutics, gaining GT005 gene therapy for geographic atrophy (dry AMD).
Novartis discontinued GT005 after clinical data failed to show sufficient efficacy, joining multiple failed GA gene therapy attempts.
Novartis halted GT-005 Phase 3 HORIZON/EXPLORE trials after interim futility analysis. Core asset from $1.5B Gyroscope acquisition failed to advance; program terminated.
GT005 failed clinically, program discontinued. $1.5B write-off adding to Novartis's gene therapy challenges.
| Deal | Year | Value | Outcome |
|---|---|---|---|
| Novartis AG / Gyroscope Therapeutics (this deal) | 2021 | $1.5B | 23 |
| Novartis AG / Advanced Accelerator Applications S.A. | 2017 | $3.9B | 98 |
| Novartis AG / Endocyte, Inc. | 2018 | $2.1B | 96 |
| Novartis AG / Lek Pharmaceuticals d.d. | 2002 | $876M | 88 |
| Novartis AG / GlaxoSmithKline plc | 2014 | $16.0B | 81 |
| Novartis AG / PTC Therapeutics Inc. | 2024 | $2.9B | 80 |
| Novartis AG / Chinook Therapeutics Inc. | 2023 | $3.5B | 78 |
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More: 2021 deals · Novartis AG deals · Gene Therapy deals