Pharma BD Deal Intelligence

Novartis AG / Aduro Biotech, Inc. (STING pathway program)

2015 · Co-Development · $750M · Terminated

Outcome grade pending — assessed 5 years post-close.

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The coverage arc

Dec 11, 2019 Endpoints News Bearish

Endpoints framed Novartis's December 2019 termination of ADU-S100 as 'the latest in a long line of setbacks' for Aduro after the $750M 2015 alliance — a clear…

Dec 11, 2019 StreetInsider / Aduro Biotech Bearish

Aduro disclosed Novartis 'removed ADU-S100 (MIW815) from its portfolio based on clinical data generated to date,' explicitly noting the decision was not driven…

Oct 25, 2022 Clinical Cancer Research (AACR) Bearish

Published Phase 1b data confirmed ADU-S100 + spartalizumab achieved only ~10.4% ORR with no expansion cohorts opened — independent peer-reviewed validation of…

Source summaries from our enrichment pipeline; follow links for originals.

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Novartis and Aduro entered an up-to-$750M global cancer immunotherapy collaboration targeting the STING pathway. Aduro received $200M upfront plus equity investment with up to $500M+ in milestones plus royalties; the partners co-developed STING agonists with Novartis launching a new immuno-oncology research group. Novartis later terminated work on STING program (2019).

Key facts

Related deals — scored

DealYearValueOutcome
Novartis AG / Aduro Biotech, Inc. (STING pathway program) (this deal)2015$750M
Novartis AG / Advanced Accelerator Applications S.A.2017$3.9B98
Novartis AG / Endocyte, Inc.2018$2.1B96
Novartis AG / Lek Pharmaceuticals d.d.2002$876M88
Novartis AG / GlaxoSmithKline plc2014$16.0B81
Novartis AG / PTC Therapeutics Inc.2024$2.9B80
Novartis AG / Chinook Therapeutics Inc.2023$3.5B78

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