Pharma BD Deal Intelligence

Merck & Co. Inc. / Protillion Biosciences, Inc.

2026 · Co-Development · $510M · Complete

CALLED IT — OFF BY 12

Early platform collaboration; optionality over near-term value

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The coverage arc

Jun 16, 2026 BusinessWire — Protillion / Merck Bullish

Protillion Biosciences announces drug discovery collaboration with Merck; undisclosed upfront plus up to $510M in milestones, leveraging the Prot-MaP platform.

Jun 16, 2026 Fierce Biotech Neutral

Merck inks $510M biobucks data-generation partnership with Protillion.

Jun 16, 2026 GEN (Genetic Engineering & Biotechnology News) Neutral

Merck, Protillion launch AI drug discovery collaboration with up to $510M in milestone payments; initial programs target inflammatory diseases.

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On June 16, 2026, Merck & Co. and Protillion Biosciences announced a drug-discovery collaboration. Protillion is eligible for an undisclosed upfront payment plus up to $510 million in research, development, and commercial milestones. The collaboration applies Protillion's Prot-MaP (Protein Display on a Massively Parallel Array) platform — which can test up to ~1 million protein variants in a single experiment to generate training data for AI-driven protein/biologics design — alongside Merck's drug-discovery capabilities. Initial programs target inflammatory diseases, with potential expansion to additional therapeutic areas.

Key facts

Related deals — scored

DealYearValueOutcome
Merck & Co. Inc. / Protillion Biosciences, Inc. (this deal)2026$510M48
Merck & Co. Inc. / Acceleron Pharma Inc.2021$11.5B90
Merck & Co. Inc. / Peloton Therapeutics Inc.2019$2.2B88
Merck & Co. Inc. / AstraZeneca PLC2017$8.5B87
Merck & Co. Inc. / Moderna, Inc.2022$250M86
Merck & Co. Inc. / Moderna, Inc.2016$250M84
Merck & Co. Inc. / Eisai Co., Ltd.2018$5.8B83

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