Pharma BD Deal Intelligence
Ranks computed across 828 graded deals (Critic + Outcome Score both present).
FDA lifted the U.S. partial clinical hold on the Phase 3 IDeate-Lung02 trial of ifinatamab deruxtecan on Jan 13, 2026; EU hold remained in place.
FDA accepted the BLA and granted Priority Review for I-DXd in previously treated ES-SCLC; PDUFA action date October 10, 2026.
Daiichi Sankyo and Merck announce global development and commercialization collaboration for three Daiichi Sankyo DXd ADCs. Merck will pay a $4 billion upfront…
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Merck entered a global development and commercialization collaboration with Daiichi Sankyo for three DXd-based ADC candidates, paying $4 billion upfront plus $1.5 billion in continuation payments, with up to $16.5 billion in additional sales milestones (total potential value up to $22 billion); Daiichi Sankyo retains exclusive rights in Japan and is solely responsible for manufacturing. The collaboration was expanded in August 2024 to add gocatamig (MK-6070/DS3280). Outcomes have been mixed: patritumab deruxtecan (HER3-DXd) failed FDA review for NSCLC and was withdrawn. Ifinatamab deruxtecan (I-DXd) had its Phase 3 IDeate-Lung02 trial placed on a U.S. partial clinical hold in late 2025 over excess ILD-related deaths, but the FDA lifted that hold in January 2026 (the EU hold remained), and in April 2026 the FDA accepted I-DXd's BLA for previously treated extensive-stage small cell lung cancer with Priority Review (PDUFA action date October 10, 2026). Raludotatug deruxtecan (R-DXd, CDH6-targeted) completed dose optimization in the REJOICE-Ovarian01 study (5.6 mg/kg selected) and advanced to the Phase 3 portion in platinum-resistant ovarian cancer.
| Deal | Year | Value | Outcome |
|---|---|---|---|
| Merck & Co. Inc. / Daiichi Sankyo Company, Limited (this deal) | 2023 | $22.0B | 68 |
| Merck & Co. Inc. / Acceleron Pharma Inc. | 2021 | $11.5B | 90 |
| Merck & Co. Inc. / Peloton Therapeutics Inc. | 2019 | $2.2B | 88 |
| Merck & Co. Inc. / AstraZeneca PLC | 2017 | $8.5B | 87 |
| Merck & Co. Inc. / Moderna, Inc. | 2022 | $250M | 86 |
| Merck & Co. Inc. / Moderna, Inc. | 2016 | $250M | 84 |
| Merck & Co. Inc. / Eisai Co., Ltd. | 2018 | $5.8B | 83 |
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